Zibotentan, CAS 186497-07-4

Formulation: A crystalline solid

Formal Name: N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide

Purity: ≥98%

Formula Markup: C19H16N6O4S

Formula Weight: 424,4

Shelf life (days): 1460

CAS Number: 186497-07-4

Notes: Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively).{40680} It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1; Item No. 24127) in vitro.{40681} Zibotentan reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2, mediators of cell invasion and angiogenesis, in HEY cells. In vivo, zibotentan (10-50 mg/kg per day) reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner. Formulations containing zibotentan are under clinical investigation for the treatment of ovarian and castration-resistant prostate cancers.

• Artikelnummer: CAY23702-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23702-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK