ZLY032, CAS 2314465-67-1

Formulation: A solid

Formal Name: (3S)-2,3-dihydro-6-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]-3-benzofuranacetic acid

Purity: ≥98%

Formula Markup: C22H18F3NO4S

Formula Weight: 449,4

Shelf life (days): 730

CAS Number: 2314465-67-1

Notes: ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50 = 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50 = 102 nM in a reporter assay).{57228} It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 µM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease.{57229} It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose.

• Artikelnummer: CAY31485-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31485-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK