Zymostenol, CAS 566-97-2

Formulation: A crystalline solid

Formal Name: (5α)-cholest-8-en-3β-ol

Purity: ≥95%

Formula Markup: C27H46O

Formula Weight: 386,7

Shelf life (days): 730

CAS Number: 566-97-2

Notes: Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.{48201} It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ) with an EC50 value of 1 µM in a RORγ coactivator recruitment assay in the presence of ursolic acid (Item No. 10072). It increases the number of myelin basic protein-positive oligodendrocytes generated from oligodendrocyte precursor cells in vitro.{48202} Zymostenol accumulates in cells following administration of microsomal antiestrogen-binding site (AEBS) ligands, such as tamoxifen (Item No. 13258), which are associated with cell differentiation and a protective type of autophagy.{48203,48204} When used alone at a concentration of 20 µM, zymostenol halts the cell cycle at the G0/G1 phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells.{48203}

• Artikelnummer: CAY26209-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26209-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK