JNJ-42226314, CAS 1252765-13-1

Formulation: A solid

Formal Name: [4-[1-[[1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl]-3-azetidinyl]-1-piperazinyl]-2-thiazolyl-methanone

Purity: ≥98%

Formula Markup: C26H24FN5O2S

Formula Weight: 489,6

Shelf life (days): 1460

CAS Number: 1252765-13-1

Notes: JNJ-42226314 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 10 nM).{72423} It is selective for MAGL over a panel of 15 serine proteases at 10 µM. JNJ-42226314 (30 mg/kg) increases the latency to paw withdrawal in the hot plate test and the brain levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in rats. It increases the latency to fall asleep and the development of non-rapid eye movement (NREM) and REM sleep, as well as increases the cortical levels of norepinephrine, in rats when administered at a dose of 30 mg/kg.{72424} Radiolabeled forms of JNJ-42226314 have been used for autoradiography and PET tracers for MAGL in the brains of rats and rhesus monkeys.{72425}

• Artikelnummer: CAY41115-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41115-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK