2-deoxy-D-Glucose-13C6

Formulation: A solid

Formal Name: (4R,5S,6R)-6-(hydroxymethyl-13C)tetrahydro-2H-pyran-2,4,5-triol-2,3,4,5,6-13C5

Purity: ≥95% (mixture of isomers)

Formula Markup: [13C]6H8O5

Formula Weight: 170,1

Shelf life (days): 1460

Notes: 2-deoxy-D-Glucose-13C6 is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose (Item No. 14325) by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.{22664,61618} It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.{22666} 2-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.{61619,22663} In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).{61620}

• Artikelnummer: CAY34312-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34312-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung