D-Mannose, CAS 3458-28-4

Formulation: A crystalline solid

Purity: ≥95%

Formula Markup: C6H12O6

Formula Weight: 180,2

Shelf life (days): 1460

CAS Number: 3458-28-4

Notes: D-Mannose is an aldohexose monosaccharide and an epimer of glucose. D-Mannose is found in animals, microbes, and plants, can be used as an energy source by conversion to glucose, and can also be produced from glucose.{30551} It is converted via hexokinase to mannose-6-phosphate and then to intermediates that are incorporated into proteins via N-linked glycosylation. It decreases T cell proliferation and increases FoxP3+ T regulatory cells in vitro and prevents diabetes in non-obese diabetic (NOD) mice, a model of autoimmune diabetes, when administered at a dose of 1.1 M in the drinking water.{43946} D-Mannose administration during gestation at a dose of 9 mg/ml in the drinking water rescues the embryonic lethal phenotype and prevents deficits in glycosylation in Pmm2R137H/F118L mice, a transgenic model of the congenital glycosylation disorder (CDG) PMM2-CDG, which is characterized by phosphomannomutase 2 (PMM2) gene mutations.{43947} Levels of D-mannose are reduced in the serum of patients with PMM2-CDG.{43948} Formulations containing D-mannose have been used in the treatment of mannose phosphate isomerase CDG (MPI-CDG).

• Artikelnummer: CAY27388-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27388-100
• Verpackungseinheit: 100 g
• Mengeneinheit: STK