L-168,049, CAS 191034-25-0

Formulation: A solid

Formal Name: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]-pyridine

Purity: ≥98%

Formula Markup: C24H20BrClN2O

Formula Weight: 467,8

Shelf life (days): 1460

CAS Number: 191034-25-0

Notes: L-168,049 is a glucagon receptor (GCGR) antagonist (IC50s = 3.7 and 179 nM in the absence and presence of MgCl2, respectively).{69829} It prevents glucagon-induced increases in IL-1β and IL-6 levels in, and levels secreted from, HepG2 cells when used at a concentration of 3.7 nM.{69830} L-168,049 inhibits glucagon-induced increases in the mRNA encoding complement 3 (C3), C-reactive protein (CRP), and fibrinogen in HepG2 cells. In vivo, L-168,049 (1 µM in drinking water) inhibits glucagon-induced increases in the hepatic levels of NOD-like receptor protein 3 (NLRP3), phosphorylated NF-κB, and phosphorylated Stat3 in mice.

• Artikelnummer: CAY41112-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41112-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK