L-694,247 (trifluoroacetate salt)

Formulation: A crystalline solid

Formal Name: N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]-methanesulfonamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C20H21N5O3S • XCF3COOH

Formula Weight: 411,5

Shelf life (days): 1460

Notes: L-694,247 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1D.{57974} It is selective for 5-HT1D over the 5-HT1A, 5-HT1C, 5-HT1E, 5-HT2, and 5-HT3 receptors (Kis = 0.093, 2.29, 380, 2,187, 316, and >10,000 nM, respectively). L-694,247 inhibits adenylyl cyclase activity induced by forskolin (Item No. 11018) in guinea pig substantia nigra homogenates and potassium-induced 5-HT release in isolated guinea pig frontal cortex strips (EC50s = 0.79 and 0.4 nM, respectively). It decreases water intake in dehydrated rats as well as prevents carbachol-, angiotensin II-, or isoproterenol-induced increases in water intake in normohydrated rats in a dose-dependent manner.{57975} Intra-atrial administration of L-694,247 (0.00000125-0.1 µg/kg) decreases renal perfusion pressure but does not affect systolic blood pressure or heart rate in in situ autoperfused rat kidney infused with phenylephrine (Item Nos. 17205 / 18619).{40402}

• Artikelnummer: CAY40639-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40639-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK