Formulation: A solid
Formal Name: trans-4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]-cyclohexaneacetic acid
Purity: ≥98%
Formula Markup: C25H24F3N3O2
Formula Weight: 455,5
Shelf life (days): 1460
CAS Number: 956136-95-1
Notes: LCQ-908 is an inhibitor of diacylglycerol acyltransferase 1 (DGAT1; IC50 = 57 nM).{72537} It is selective for DGAT1 over DGAT2, acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), and ACAT-2 (IC50s = >10,000 nM for all). LCQ-908 (50 µM) also inhibits hepatitis C virus (HCV) replication in HCV-infected Huh7.5 cells.{72538} It inhibits palmitic acid-induced apoptosis and increases in triglyceride levels in MIN6 pancreatic β-cells when used at a concentration of 1 µM.{72539} In vivo, LCQ-908 (1 mg/kg) decreases serum triglyceride levels in an oral lipid tolerance test in dogs.{72537}
Deutsch
English
