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OLR1 Recombinant Protein
OLR1 Recombinant Protein
Artikelnummer
AVIOPCD04985-50
Verpackungseinheit
50µg
Hersteller
Aviva Systems Biology
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Conjugation: Unconjugated
Description of Target: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Molecular Weight: 26kDa
Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Protein Name: Oxidized low-density lipoprotein receptor 1
Protein Size: Recombinant
Purity: > 97%
Source: E.coli
Tag: N-terminal His Tag
Description of Target: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Molecular Weight: 26kDa
Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Protein Name: Oxidized low-density lipoprotein receptor 1
Protein Size: Recombinant
Purity: > 97%
Source: E.coli
Tag: N-terminal His Tag
| Artikelnummer | AVIOPCD04985-50 |
|---|---|
| Hersteller | Aviva Systems Biology |
| Hersteller Artikelnummer | OPCD04985-50UG |
| Green Labware | Nein |
| Verpackungseinheit | 50µg |
| Mengeneinheit | STK |
| Reaktivität | Human |
| Methode | Western Blotting, Positive Control, SDS-PAGE |
| Human Gene ID | 4973 |
| Wirt | Escherichia Coli |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
