Recombinant Cynomolgus NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)

Protein Construction: Recombinant Cynomolgus NKG2-D type II Integral Membrane Protein is produced by our Mammalian expression system and the target gene encoding Phe78-Val216 is expressed with a 6His tag at the N-terminus.

Sequence: Phe78-Val216.

Fusion tag: N-6His.

Accession: P61252.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Mol Mass: 16.9 kDa.

AP Mol Mass: 22-35 kDa.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Background: NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

• Artikelnummer: ELSPKSQ050115-10
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PKSQ050115-10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK
• Reaktivität: Cynomolgus Monkey (Primate)
• Wirt: Human