Protein Construction: Recombinant Human Asialoglycoprotein Receptor 1 is produced by our Mammalian expression system and the target gene encoding Gln62-Ile291 is expressed with a 6His tag at the C-terminus.
Sequence: Gln62-Ile291.
Fusion tag: C-6His.
Accession: P07306.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Mol Mass: 27.4 kDa.
AP Mol Mass: 38 kDa.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Background: Asialoglycoprotein Receptor 1 (ASGPR1) is an endocytic recycling receptor; belongs to the long-form subfamily of the C-type/Ca2+-dependent lectin family. ASGPR consists of two noncovalently-linked subnits; ASGPR1 and ASGPR2. ASGPR1 mediates the endocytosis of plasma glycoproteins; recognizes terminal galactose and N-acetylgalactosamine units. When the ligand binds to to ASGPR1; results in the complex is internalized and transported to a sorting organelle; then ASGPR1 and ligand can be disassociated; ASGPR1 returns to the cell membrane surface.