Recombinant Human DC-SIGNR/CD299 (N-8His-Flag)

Protein Construction: Recombinant Human C-type Lectin Domain Family 4 Member M is produced by our Mammalian expression system and the target gene encoding Ser73-Glu376 is expressed with a 8His, Flag tag at the N-terminus.

Sequence: Ser73-Glu376.

Fusion tag: N-8His-Flag.

Accession: Q9H2X3-8.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Mol Mass: 37 kDa.

AP Mol Mass: 35-40 kDa.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Background: CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation.

• Artikelnummer: ELSPKSH033990-50
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PKSH033990-50
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Wirt: Human