Recombinant Human Siglec-7/CD328 (C-6His)

Protein Construction: Recombinant Human Sialic Acid-binding Ig-like Lectin 7 is produced by our Mammalian expression system and the target gene encoding Gln19-Leu353 is expressed with a 6His tag at the C-terminus.

Sequence: Gln19-Leu353.

Fusion tag: C-6His.

Accession: Q9Y286.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Mol Mass: 37.8 kDa.

AP Mol Mass: 50-70 kDa.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Background: Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.

• Artikelnummer: ELSPKSH033850-50
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PKSH033850-50
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Wirt: Human