LGD 3033, CAS 917891-35-1

Formulation: A solid

Formal Name: 9-chloro-2-ethyl-3,6-dihydro-1-methyl-3-(2,2,2-trifluoroethyl)-7H-pyrrolo[3,2-f]quinolin-7-one

Purity: ≥98%

Formula Markup: C16H14ClF3N2O

Formula Weight: 342,7

Shelf life (days): 1460

CAS Number: 917891-35-1

Notes: LGD 3033 is an androgen receptor agonist.{72237} It selectively binds to the androgen receptor (Ki = 0.9 nM for the human receptor) over mineralocorticoid, glucocorticoid, and progesterone receptors (Kis = 1,261, 581, and 136 nM, respectively, for the human receptors). It also selectively induces reporter transcription in a reporter assay using CV-1 cells expressing the androgen receptor (EC50 = 3.6 nM) over CV-1 cells expressing the mineralocorticoid or progesterone receptors (EC50s = 3,695 and 2,233 nM, respectively). LGD 3033 (3 mg/kg per day) increases levator ani muscle mass, but not prostate muscle mass, in orchiectomized (ORDX) male rats. It increases body weight and gastrocnemius mass, bone mineral content and density in the lumbar spine and mid-femur, and bone formation rate in ovariectomized (OVX) female rats when administered at a dose of 3 mg/kg per day. LGD 3033 (30 mg/kg per day) increases the time spent in the male area in a sexual preference test by sexually experienced, but not sexually inexperienced, estradiol benzoate- and progesterone-primed OVX female rats.{72238}

• Artikelnummer: CAY40143-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40143-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK