Formulation: A solution in ethanol
Formal Name: (S)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxoheptyl)thio]-3,5-dioxa-9-thia-4-phosphahexadecan-1-aminium
Purity: ≥95%
Formula Markup: C22H44NO6PS2
Formula Weight: 513,7
Shelf life (days): 365
CAS Number: 89019-63-6
Notes: 1,2-bis(heptanoylthio) Glycerophosphocholine (Diheptanoyl Thio-PC) is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).{5681} Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.{1358,1359}