1-Deoxysphinganine (m18:0), CAS 196497-48-0

Formulation: A crystalline solid

Formal Name: 2S-amino-3R-octadecanol

Purity: ≥95%

Formula Markup: C18H39NO

Formula Weight: 285,5

Shelf life (days): 730

CAS Number: 196497-48-0

Notes: 1-Deoxysphinganine is an atypical sphingolipid that lacks the C1-hydroxyl group of canonical sphinganine and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.{17311} Plasma levels of 1-deoxysphinganine are increased in patients with hereditary sensory and autonomic neuropathy type 1 (HSAN1), an inherited neuropathy associated with serine palmitoyltransferase gene mutations, and in patients with glycogen storage disease type I (GSDI).{42288,36918} Deoxysphingolipids, including 1-deoxysphinganine, are not converted to canonical sphingolipids or fatty acids and accumulate in cells, particularly in the mitochondria where 1-deoxysphinganine induces mitochondrial fragmentation and dysfunction.{42285} It also accumulates in LLC-PK1 cells and in mouse liver and kidney following application or administration, respectively, of the ceramide synthase inhibitor fumonisin B1 (Item No. 62580).{17311} 1-Deoxysphinganine is neurotoxic to dorsal root ganglion neurons in vitro, decreasing neurite length and inducing neurite contraction when used at a concentration 1 µM.{42288} It is cytotoxic to DU145 cells (IC50 = ~2 µM) but stimulates DNA synthesis in Swiss 3T3 cells when used at a concentration of 1 µM.{17311,36917}

• Artikelnummer: CAY13511-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13511-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK