10-oxo-12(Z)-Octadecenoic Acid, CAS 103521-29-5

Formulation: A solution in ethanol

Purity: ≥95%

Formula Markup: C18H32O3

Formula Weight: 296,5

Shelf life (days): 730

CAS Number: 103521-29-5

Notes: 10-oxo-12(Z)-Octadecenoic acid is a metabolite of linoleic acid (Item Nos. 90150 / 90150.1 / 21909) and an activator of transient receptor potential vanilloid 1 (TRPV1).{62769,62768} It is formed from linoleic acid by conjugated linoleic acid dehydrogenase (CLA-DH) via a 10-hydroxy-12(Z)-octadecenoic acid intermediate and can also be produced from linoleic acid by gut microbiota.{62769} 10-oxo-12(Z)-Octadecenoic acid (100 µM) selectively increases calcium levels in HEK293 cells expressing TRPV1 over those expressing TRPV2, TRPV3, TRPV4, and TRP melastatin 8 (TRPM8).{62768} It also induces inward currents in HEK293 cells expressing TRPV1, an effect that can be blocked by the TRPV1 antagonist capsazepine (Item No. 10007518). Dietary administration of 10-oxo-12(Z)-octadecenoic acid (0.1% w/w) reduces weight gain and adipose tissue weight and increases the expression of the gene encoding mitochondrial uncoupling protein 1 (Ucp1) in wild-type, but not Trpv1 knockout, mice fed a high-fat diet. It also decreases plasma glucose and triglyceride levels in diabetic KKAy mice fed a high-fat diet.

• Artikelnummer: CAY36977-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36977-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Reinstoffe