11-deoxy-11-methylene Prostaglandin D2, CAS 100648-29-1

Formulation: A solution in methyl acetate

Formal Name: 9α,15S-dihydroxy-11-methylene-prosta-5Z,13E-dien-1-oic acid

Purity: ≥98%

Formula Markup: C21H34O4

Formula Weight: 350,5

Shelf life (days): 365

CAS Number: 100648-29-1

Notes: Prostaglandin D2 (PGD2; Item No. 12010) is one of the five primary enzymatic prostaglandins derived directly from PGH2 (Item No. 17020). PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase.{9588} PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin.{7894} However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.{11175} The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported.

• Artikelnummer: CAY12410-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 12410-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK