11-trans Leukotriene C4, CAS 74841-69-3

Formulation: A solution in ethanol

Formal Name: 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11E,14Z-eicosatetraenoic acid

Purity: ≥97%

Formula Markup: C30H47N3O9S

Formula Weight: 625,8

Shelf life (days): 365

CAS Number: 74841-69-3

Notes: 11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils{11135}, but not in human neutrophils or RBL-1 cells.{11184} It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.{2070,11187} In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.{11187}

• Artikelnummer: CAY20230-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20230-25
• Green Labware: Nein
• Verpackungseinheit: 25 µg
• Mengeneinheit: STK