11β-Prostaglandin F2α, CAS 38432-87-0

Formulation: A crystalline solid

Formal Name: (5Z,9α,11β,13E,15S)-9,11,15-trihydroxy-prosta-5,13-dien-1-oic acid

Purity: ≥98%

Formula Markup: C20H34O5

Formula Weight: 354,5

Shelf life (days): 730

CAS Number: 38432-87-0

Notes: 11β-Prostaglandin F2α (11β-PGF2α) is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}

• Artikelnummer: CAY16520-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16520-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK