11β-Prostaglandin F2α-d9, CAS 2738376-79-7

Formulation: A solution in ethanol

Formal Name: (Z)-7-((1R,2R,3S,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl-5,5,6,6,7,7,8,8,8-d9)cyclopentyl)hept-5-enoic acid

Purity: ≥99% deuterated forms (d1-d9)

Formula Markup: C20H25D9O5

Formula Weight: 363,5

Shelf life (days): 365

CAS Number: 2738376-79-7

Notes: 11β-Prostaglandin F2α-d9 (11β-PGF2α-d9) is intended for use as an internal standard for the quantification of 11β-PGF2α (Item No. 16520) by GC- or LC-MS. 11β-PGF2α is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}

• Artikelnummer: CAY18788-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18788-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung