Formulation: A solution in ethanol
Formal Name: (±)-12-hydroxy-5Z,8Z,10E,14Z,17Z-eicosapentaenoic acid
Purity: ≥98%
Formula Markup: C20H30O3
Formula Weight: 318,5
Shelf life (days): 365
CAS Number: 81187-21-5
Notes: (±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 µM, respectively.{11169} These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s = 8.6-8.8 µM).{7481}