Formulation: A solution in ethanol
Formal Name: (±)12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Purity: ≥95%
Formula Markup: C20H32O3
Formula Weight: 320,5
Shelf life (days): 730
CAS Number: 71030-37-0
Notes: (±)12-HETE is a racemic mixture of the arachidonic acid metabolites 12(R)-HETE (Item No. 34560) and 12(S)-HETE (Item No. 34570). It is formed via non-enzymatic oxidation of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{54364,54411} 12(S)- and 12(R)-HETE are formed by 12S- and 12R-lipoxygenase-mediated oxidation of arachidonic acid, respectively.{59716,54718,584} 12(R)-HETE can also be formed by oxidation of arachidonic acid mediated by cytochrome P450 (CYP450) enzymes.{54364} (±)12-HETE (1 µM) induces aggregation of isolated human neutrophils.{2091} Production of (±)12-HETE by platelets isolated from spontaneously hypertensive rats is increased compared with platelets isolated from normotensive rats.{3138}