12-keto Lithocholic Acid, CAS 5130-29-0

Formulation: A solid

Formal Name: (3α,5β)-3-hydroxy-12-oxo-cholan-24-oic acid

Purity: ≥98%

Formula Markup: C24H38O4

Formula Weight: 390,6

Shelf life (days): 1460

CAS Number: 5130-29-0

Notes: 12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA; Item Nos. 20756 / 18231).{46886,46887} Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Item No. 20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol (Item No. 9003100), hyodeoxycholic acid (HDCA; Item No. 20294), or lithocholic acid (LCA; Item No. 20253).{46887} 12-keto Lithocholic acid activates the human pregnane X receptor (PXR; EC50 = 31.3 μM in a cell-based transactivation assay).{46888} 12-keto Lithocholic acid levels are increased in duodenal bile from patients with type 2 diabetes.{46889}

• Artikelnummer: CAY29547-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29547-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK