12-oxo Leukotriene B4, CAS 136696-10-1

Formulation: A solution in acetonitrile

Formal Name: 5S-hydroxy-12-oxo-6Z,8E,10E,14Z-eicosatetraenoic acid

Purity: ≥90%

Formula Markup: C20H30O4

Formula Weight: 334,4

Shelf life (days): 365

CAS Number: 136696-10-1

Notes: Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway.{1370,16836,1226} It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4.{16836} 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils.{16835} It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.{16835}

• Artikelnummer: CAY20140-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20140-50
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK