14,15-dehydro Leukotriene B4, CAS 114616-11-4

Formulation: A solution in ethanol

Formal Name: 5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid

Purity: ≥97%

Formula Markup: C20H30O4

Formula Weight: 334,5

Shelf life (days): 365

CAS Number: 114616-11-4

Notes: Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.{521,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.{329,82} At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.{8743} 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.{384}

• Artikelnummer: CAY20150-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20150-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK