(±)14(15)-EET, CAS 197508-62-6

Formulation: A solution in ethanol

Formal Name: (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid

Purity: ≥98%

Formula Markup: C20H32O3

Formula Weight: 320,5

Shelf life (days): 730

CAS Number: 197508-62-6

Notes: (±)14(15)-EET is a metabolite of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450.{463,729} It prevents increases in leukotriene B4 (LTB4; Item No. 20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.{60003} (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).{12606} It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.{60004}

• Artikelnummer: CAY50651-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 50651-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK