14,15-Leukotriene E4, CAS 1000852-57-2

Formulation: A solution in methanol

Formal Name: 15S-hydroxy-14R-(S-cysteinyl)-5Z,8Z,10E,12E-eicosatetraenoic acid

Purity: ≥97%

Formula Markup: C23H37NO5S

Formula Weight: 439,6

Shelf life (days): 365

CAS Number: 1000852-57-2

Notes: Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} These metabolites are classified as eoxins because they are formed mostly by eosinophils.{15256} Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.{15256}

• Artikelnummer: CAY10011362-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10011362-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK