15-deoxy-Δ12,14-Prostaglandin D2-d4, CAS 2750534-91-7

Formulation: A solution in methyl acetate

Formal Name: rac-(Z)-7-((1R,5S,E)-5-hydroxy-2-((E)-oct-2-en-1-ylidene)-3-oxocyclopentyl)hept-5-enoic-3,3,4,4-d4 acid

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C20H26D4O4

Formula Weight: 338,5

Shelf life (days): 730

CAS Number: 2750534-91-7

Notes: 15-deoxy-Δ12,14-Prostaglandin D2-d4 (15-deoxy-Δ12,14-PGD2-d4) is an internal standard for the quantification of 15-deoxy-Δ12,14-PGD2 (Item No. 12700) by GC- or LC-MS. 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}

• Artikelnummer: CAY19343
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19343-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung