15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester, CAS 130273-87-9

Formulation: A solution in methyl acetate

Formal Name: 9α,11α,15R-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester

Purity: ≥98%

Formula Markup: C26H38O5

Formula Weight: 430,6

Shelf life (days): 730

CAS Number: 130273-87-9

Notes: 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.{9736} A 3 µg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.{9736}

• Artikelnummer: CAY16825-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16825-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK