15(R)-Lipoxin A4, CAS 171030-11-8

Formulation: A solution in ethanol

Formal Name: 5(S),6(R),15(R)-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid

Purity: ≥95%

Formula Markup: C20H32O5

Formula Weight: 352,5

Shelf life (days): 365

CAS Number: 171030-11-8

Notes: Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE (Item No. 34710) from arachidonic acid (Item No. 90010).{3520,2629} 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 (Item No. 90410) demonstrating activity in the nM range.{2629,11078} The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.{15182} 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.{29947}

• Artikelnummer: CAY90415-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 90415-250
• Green Labware: Nein
• Verpackungseinheit: 250 µg
• Mengeneinheit: STK