17(R)-Resolvin D1 methyl ester, CAS 937738-64-2

Formulation: A solution in ethanol

Formal Name: 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid, methyl ester

Purity: ≥95%

Formula Markup: C23H34O5

Formula Weight: 390,5

Shelf life (days): 365

CAS Number: 937738-64-2

Notes: 17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 (Item No. 10012554) that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).{15718} 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.{15718} In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. 17(R)-RvD1 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.

• Artikelnummer: CAY9001072-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001072-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK