Formulation: A solution in ethanol
Formal Name: (±)18-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
Purity: ≥97%
Formula Markup: C20H32O3
Formula Weight: 320,5
Shelf life (days): 730
CAS Number: 133268-58-3
Notes: (±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer.{15766} 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure.{3825} 18-HETE has negligible effects on ATPase activity.{3825} 18(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles.{15772}