2,3-dinor-8-iso Prostaglandin F1α, CAS 221664-04-6

Formulation: A solution in methyl acetate

Formal Name: 3R,5S-dihydroxy-2R-[(1E,3S)-3-hydroxy-1S-octen-1-yl]-cyclopentanepentanoic acid

Purity: ≥98%

Formula Markup: C18H32O5

Formula Weight: 328,4

Shelf life (days): 365

CAS Number: 221664-04-6

Notes: DMSO 2,3-dinor-8-iso Prostaglandin F1α (2,3-dinor-8-iso PGF1α) is an isoprostane and active metabolite of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) and the platelet aggregation inhibitor 8-iso PGF2α (Item No. 16350).{66406,3026} It is formed by the non-enzymatic, free radical peroxidation of arachidonic acid.{66406} 2,3-dinor-8-iso PGF1α induces vasoconstriction in isolated porcine retinal and brain microvessels (EC50s = 12.8 and 18.5 nM, respectively) but does not induce contraction of isolated rat aortic rings when used at a concentration of 31 µM.{66406,11221} It increases thromboxane B2 (TXB2; Item No. 19030) levels in isolated porcine brain slices when used at a concentration of 1 µM, an effect that can be reversed by the thromboxane A synthase inhibitor CGS 12970, the voltage-gated calcium channel inhibitor SKF 96365 (Item No. 10009312), or nicotinic acetylcholine receptor (nAChR) antagonist α-conotoxin.{66406}

• Artikelnummer: CAY15290-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15290-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Reinstoffe