2-chloro Palmitic Acid, CAS 19117-92-1

Formulation: A crystalline solid

Formal Name: 2-chloro-hexadecanoic acid

Purity: ≥95%

Formula Markup: C16H31ClO2

Formula Weight: 290,9

Shelf life (days): 730

CAS Number: 19117-92-1

Notes: 2-chloro Palmitic acid is a monochlorinated form of palmitic acid (Item No. 10006627). It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli.{43363} It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM.{43481,43482} 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.{43483}

• Artikelnummer: CAY26107-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26107-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK