(±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide, CAS 166100-39-6

Formulation: A solution in ethanol

Formal Name: (±)-N-(2-fluoroethyl)-2-methyl-5Z,8Z,11Z,14Z-eicosatetraenamide

Purity: ≥95%

Formula Markup: C23H38FNO

Formula Weight: 363,6

Shelf life (days): 730

CAS Number: 166100-39-6

Notes: (±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB1 receptor (Ki = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB2 is decreased relative to AEA.{7422} However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2'-fluoro AEA is further modified by the addition of an α-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2'-fluoro AEA can fully substitute for Δ9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot.{8152}

• Artikelnummer: CAY90055-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 90055-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK