25-hydroxy Cholesterol, CAS 2140-46-7

Formulation: A crystalline solid

Formal Name: cholest-5-ene-3β,25-diol

Purity: ≥98%

Formula Markup: C27H46O2

Formula Weight: 402,7

Shelf life (days): 1460

CAS Number: 2140-46-7

Notes: 25-hydroxy Cholesterol is an oxysterol.{20437} It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.{60052} 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM).{20445} 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection.{60053} It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.

• Artikelnummer: CAY11097-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11097-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK