4-hydroxy Estrone, CAS 3131-23-5

Formulation: A solid

Formal Name: 3,4-dihydroxy-estra-1,3,5(10)-trien-17-one

Purity: ≥95%

Formula Markup: C18H22O3

Formula Weight: 286,4

Shelf life (days): 1460

CAS Number: 3131-23-5

Notes: 4-hydroxy Estrone is a metabolite of the endogenous estrogen estrone (Item No. 10006485).{57564} It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1B1, CYP1A2, and CYP1A1. 4-hydroxy Estrone (5 µM) induces nuclear translocation of phosphorylated p53 and is protective against glutamate-induced oxidative death in HT22 hippocampal neuronal cells.{57565} It reduces neurodegeneration induced by kainic acid in the rat hippocampus and improves working memory in the Y-maze in rats when administered at a dose of 10 µg/animal. 4-hydroxy Estrone also inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC50 values of 30 and 38 µM, respectively.{28444}

• Artikelnummer: CAY33696-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33696-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK