Formulation: A solution in methyl acetate
Formal Name: (±)-4-hydroxy-9,9,9-d3-non-2E-enal
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C9H13D3O2
Formula Weight: 159,2
Shelf life (days): 365
CAS Number: 148706-06-3
Notes: 4-hydroxy Nonenal-d3 (4-HNF-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE by GC- or LC-mass spectrometry. 4-HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.{869,1103} 4-HNE is widely used as a marker of lipid peroxidation.{1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.{869,1103,1109} 4-HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.{1103}