4-hydroxy Nonenal Mercapturic Acid, CAS 146764-24-1

Formulation: A solution in ethanol

Formal Name: N-acetyl-S-(tetrahydro-5-hydroxy-2-pentyl-3-furanyl)-L-cysteine

Purity: ≥98%

Formula Markup: C14H25NO5S

Formula Weight: 319,4

Shelf life (days): 365

CAS Number: 146764-24-1

Notes: Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat.{7334} About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates.{8626} The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo.

• Artikelnummer: CAY32110-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32110-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK