Formulation: A crystalline solid
Formal Name: (17β)-estra-1,3,5(10)-triene-3,4,17-triol
Purity: ≥98%
Formula Markup: C18H24O3
Formula Weight: 288,4
Shelf life (days): 1460
CAS Number: 5976-61-4
Notes: 4-Hydroxyestradiol is a catechol estrogen and minor metabolite of estrogen.{57239,57240} 4-Hydroxyestradiol is formed from estrogen by the cytochrome P450 (CYP) isoform CYP1B1.{57240} Production of 4-hydroxyestradiol is increased in microsomes prepared from human mammary adenocarcinoma and fibroadenoma microsomes compared with microsomes prepared from non-cancerous tissues.{57239} 4-Hydroxyestradiol (25 mg/animal) induces renal tumor formation in male hamsters.{57241}