Formulation: A solution in ethanol
Formal Name: (±)5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid
Purity: ≥95%
Formula Markup: C20H34O4
Formula Weight: 338,5
Shelf life (days): 365
CAS Number: 213382-49-1
Notes: 5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET (Item Nos. 50211 / 10007260) by epoxide hydrolases.{729} 5(6)-DiHET can be used to quantify 5(6)-EET due to the conversion of 5(6)-EET to 5(6)-δ-lactone in solution.{39654} 5(6)-DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in smooth muscle cells from rat small coronary arteries.{37444} It is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in vitro.{461} 5(6)-DiHET levels decrease in plasma in a high-fat diet-induced rat model of hyperlipidemia.{37445}