7-keto Cholesterol-d7, CAS 127684-08-6

Formulation: A solid

Formal Name: 3β-hydroxy-cholest-5-en-7-one-25,26,26,26,27,27,27-d7

Purity: ≥99% deuterated forms (d1-d7)

Formula Markup: C27H37D7O2

Formula Weight: 407,7

Shelf life (days): 1460

CAS Number: 127684-08-6

Notes: 7-keto Cholesterol-d7 is intended for use as an internal standard for the quantification of 7-keto cholesterol (Item No. 16339) by GC- or LC-MS. 7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL.{26766,5829} It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol (Item No. 14612) by the cytochrome P450 (CYP) isoform CYP7A1.{26764,26765,26761} 7-keto Cholesterol inhibits CYP7A1 (IC50 = ~1 μM).{26765} It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro.{39975} Intraocular implantation of 7-keto cholesterol-coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye.{39976} Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimer's disease, and age-related macular degeneration.

• Artikelnummer: CAY25972-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25972-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung