7α,25-dihydroxy Cholesterol, CAS 64907-22-8

Formulation: A crystalline solid

Formal Name: (3β,7α)-cholest-5-ene-3,7,25-triol

Purity: ≥95%

Formula Markup: C27H46O3

Formula Weight: 418,7

Shelf life (days): 730

CAS Number: 64907-22-8

Notes: GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.{19918,19919} 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).{19918,19919} At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.{19919} 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.{19918,19919}

• Artikelnummer: CAY11032-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11032-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK