7β,27-dihydroxy Cholesterol, CAS 240129-43-5

Formulation: A crystalline solid

Formal Name: (3β,7β,25R)-cholest-5-ene-3,7,26-triol

Purity: ≥95%

Formula Markup: C27H46O3

Formula Weight: 418,7

Shelf life (days): 730

CAS Number: 240129-43-5

Notes: 7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt.{33003} It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human naïve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 / 11932).

• Artikelnummer: CAY20102-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20102-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK