8-iso-13,14-dihydro-15-keto Prostaglandin F2α, CAS 191919-02-5

Formulation: A solution in methyl acetate

Formal Name: (8β)-9α,11α-dihydroxy-15-oxo-prost-5Z-en-1-oic acid

Purity: ≥98%

Formula Markup: C20H34O5

Formula Weight: 354,5

Shelf life (days): 365

CAS Number: 191919-02-5

Notes: 8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans.{6907} 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation.{320} In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.{6907} A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits.{11209} Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.{11145}

• Artikelnummer: CAY16380-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16380-50
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK