8-iso-15-keto Prostaglandin F2α, CAS 191919-01-4

Formulation: A solution in methyl acetate

Formal Name: 9α,11α-dihydroxy-15-oxo-(8β)-prosta-5Z,13E-dien-1-oic acid

Purity: ≥95%

Formula Markup: C20H32O5

Formula Weight: 352,5

Shelf life (days): 365

CAS Number: 191919-01-4

Notes: 8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation.{320} In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.{6907} A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits.{11209} Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.{11221}

• Artikelnummer: CAY16390-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16390-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK