Formulation: A solution in methyl acetate
Formal Name: 9α,11α-dihydroxy-15-oxo-(8β)-prosta-5Z,13E-dien-1-oic acid
Purity: ≥95%
Formula Markup: C20H32O5
Formula Weight: 352,5
Shelf life (days): 365
CAS Number: 191919-01-4
Notes: 8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation.{320} In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.{6907} A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits.{11209} Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.{11221}