8-iso Prostaglandin A2, CAS 474391-66-7

Formulation: A solution in methyl acetate

Formal Name: (8β)-15S-hydroxy-9-oxo-prosta-5Z,10,13E-trien-1-oic acid

Purity: ≥98%

Formula Markup: C20H30O4

Formula Weight: 334,5

Shelf life (days): 365

CAS Number: 474391-66-7

Notes: 8-iso Prostaglandin A2 (8-iso PGA2) is an isoprostane. It is produced by the non-enzymatic oxidation of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{7324,14267} 8-iso PGA2 (100 µM) induces calcium influx in HEK293 cells expressing human transient receptor potential ankyrin 1 (TRPA1) and isolated mouse trigeminal neurons.{21769} It potentiates glutamate-induced cytotoxicity and decreases glutathione (GSH) levels in HT22 hippocampal cells when used at concentrations of 1 and 30 µM, respectively.{16387} 8-iso PGA2 (10 µM) inhibits VEGF-induced migration and tube formation of human coronary artery endothelial cells, an effect that can be reversed by the TP receptor antagonist SQ 29,548 (Item No. 19025).{20091}

• Artikelnummer: CAY10235-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10235-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK